AstraZeneca-University of Cambridge (2025) Project Advertisements
1. Project Title: Partitioning the effects of high body mass index on risk of future comorbidities (Fixed Term)
Project supervisors: Dr Samuel Lambert (Assistant Professor of Health Data Science, University of Cambridge) and Dr Xiao Jiang (Senior Data Scientist, Centre for Genomics Research, AstraZeneca)
Closing Date: 31 October 2024
Applications are invited for 4-year PhD studentship (starting October 2025) based in the University of Cambridge's Cardiovascular Epidemiology Unit and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project entitled "Partitioning the effects of high body mass index on risk of future comorbidities", jointly supervised by Dr Samuel Lambert (Assistant Professor of Health Data Science, University of Cambridge) and Dr Xiao Jiang (Senior Data Scientist, Centre for Genomics Research, AstraZeneca).
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2. Project Title: Rapid development of new catalytic synthetic methodology for fragment-based drug discovery enabled by high-throughput experimentation
Project supervisors: Professor Matthew Gaunt (Cambridge) and Dr Henry Blackwell (AstraZeneca)
Closing Date: 1 December 2024
Applications are invited for a 4-year PhD studentship based in the Department of Chemistry and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Professor Matthew Gaunt (Cambridge) and Dr Henry Blackwell (AstraZeneca) and will have the opportunity to work across the two sites.
The project will develop distinct catalyst activation modes that enable the rapid assembly of novel molecular architectures that are directly applicable to fragment-based drug discovery. The project will focus on the development of methods to directly generate synthetically versatile C(sp3)-rich polar scaffolds and seek to assess representative libraries in preliminary biological screens. In addition to state-of-the-art synthetic chemistry research the project will provide exposure and training in high-throughout experimentation, computational design and medicinal chemistry.
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3. Project Title: A reproducible human lung organoid platform for large scale oncology CRISPR screens
Project supervisors: Prof Rawlins in PDN/Gurdon and Dr Luigi Aloia at AstraZeneca
Closing Date: 11 November 2024
Applications are invited for 4-year PhD studentship based in the Department of Physiology, Development and Neuroscience(PDN)/Gurdon Institute, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof Rawlins in PDN/Gurdon and Dr Luigi Aloia at AstraZeneca and will work have opportunity to work across the two sites.The project, entitled 'A reproducible human lung organoid platform for large scale oncology CRISPR screens' is in the field of human organoid/cancer biology that has generated much excitement in both academia and industry
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4. Project Title: How does the microbiota contribute to chronic pain
Project supervisors: Dr David Bulmer (Cambridge) and Dr Fraser Welsh (AstraZeneca)
Closing Date: 4 November 2024
Applications are invited for a 4-year PhD studentship based at the Department of Pharmacology, University of Cambridge and the new AstraZeneca Discovery Centre in Cambridge conducting research into how the microbiome contributes to chronic pain. The project will be jointly supervised by Dr David Bulmer (Cambridge) and Dr Fraser Welsh (AstraZeneca) and provides the student with an opportunity to work across both sites, in addition to the broader multidisciplinary team of clinicians and academics investigating the microbiome and pain at the University and Medical School. Metagenomic and metabolomic analysis supports a causative role for bacterial metabolites, which we will seek to evaluate in this studentship using functional assays of pain signalling, neuroepithelial and immune cell function, in conventional, and germ-free animals to recapitulate the dysbiotic microbial phenotype.
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5. Project Title: Uncovering the electrophysiological fingerprints of neuroendocrine cancer cells
Project supervisors: Prof Hugh Robinson, in the Department of PDN, and Dr. Philipe Mendonça at AstraZeneca
Closing Date: 11 November 2024
Applications are invited for a 4-year PhD studentship based in the Department of Physiology, Development and Neuroscience (PDN), University of Cambridge, and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof Hugh Robinson, in the Department of PDN, and Dr. Philipe Mendonça at AstraZeneca and will have the opportunity to work across the two sites. The project is in the emerging field of cancer neuroscience, which is generating great interest and excitement in both academia and industry.
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6. Project Title: Therapeutic cancer prevention of hereditary cancers
Project supervisors: Prof Walid Khaled in Pharmacology/CSCI, Dr Mark Albertella and Dr Andrew Reynolds at AstraZeneca
Closing Date: 11 November 2024
Applications are invited for a 4-year PhD studentship based in the Department Pharmacology /Cambridge Stem Cell Institute (CSCI), University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof Walid Khaled in Pharmacology/CSCI, Dr Mark Albertella and Dr Andrew Reynolds at AstraZeneca. The project, entitled "Therapeutic cancer prevention of hereditary cancers"' aims to test various therapeutic options to prevent the development of breast cancer in high-risk individuals. More details can be found in the attachments.
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7. Project Title: Conformal electronic devices for non-invasive, dynamic monitoring of barrier tissues
Project supervisors: Prof Róisín M. Owens in CEB and Dr Muireann Coen, Oncology Safety, AstraZeneca
Closing Date: 18 November 2024
Applications are invited for a 4-year PhD studentship based in the Department of Chemical Engineering and Biotechnology (CEB), University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof Róisín M. Owens in CEB and Dr Muireann Coen, Oncology Safety, AstraZeneca and will have the opportunity to work across the two sites. The project, entitled "Conformal electronic devices for non-invasive, dynamic monitoring of barrier tissues" spans the fields of bioelectronics, tissue engineering and drug discovery, and has generated much excitement in both academia and industry.
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8. Project Title: Developing the next generation of antibody-oligonucleotide conjugates using divinylpyridimidine conjugation
Project supervisors: Prof. David Spring in Chemistry, Jonathan Bargh at AstraZeneca
Applications are invited for a 4-year PhD studentship based in the Department of Chemistry, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof David Spring (Cambridge) and Dr Jonathan Bargh (AstraZeneca) and will have opportunity to work across the two sites.
The project will combine the advances in Antibody-Drug Conjugates (ADCs) with antisense oligonucleotides. ADCs have revolutionized targeted cancer therapy by delivering cytotoxic drugs to cancer cells with reduced systemic toxicity.
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9. Project Title: Multimodal and multiscale imaging: interrogating renal morphology and function across the disease landscape
Project supervisors: Prof. Ferdia Gallagher in Radiology, Richard Goodwin at AstraZeneca
Applications are invited for the Astra-Zeneca Non-Clinical PhD Studentship - Multimodal and multiscale imaging: interrogating renal morphology and function across the disease landscape. The successful applicant will be working on collaborative project jointly supervised by the Professor Ferdia Gallagher (Department of Radiology) and Dr Richard Goodwin (Astra-Zeneca) and will have the opportunity to work across both sites.
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10. Project Title: Accelerating big data in material crystallization
Project supervisors: Prof. Laura Torrente-Murciano in Chemical Engineering & Biotechnology, Will Goundry at AstraZeneca
Applications are invited for 4-year PhD studentship based in the Department of Chemical Engineering and Biotechnology (CEB), University of Cambridge and with a placement at an AstraZeneca UK site. The student will be working on a collaborative project jointly supervised by Prof Laura Torrente Murciano in CEB and Dr Sophie Janbon at AstraZeneca. The project, entitled Accelerating Big Data in material crystallization, will focus on the fundamental understanding of the mechanism and kinetics of co-precipitation and crystallization, underpinning many drug manufacturing processes despite being poorly understood.
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11. Project Title: Interaction between innate immune activation and cell cycle status in macrophages: implications for inflammatory diseases
Project supervisors: Prof. Ravindra Gupta in Medicine, Daniele Corridoni at AstraZeneca
Applications are invited for 4-year PhD studentship based in the Department of Medicine and the new AstraZeneca Discovery Centre (DISC) at Cambridge. The student will be working on a collaborative project jointly supervised by Prof Ravi Gupta and Dr. Daniele Corridoni at AstraZeneca offering the unique opportunity to work across the two sites, aiming to train independent, innovative scientists capable of pursuing translational research.
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