AZ-UoC (2024) Project advertisements
- Project Title: DNA damage and androgen pathway inhibition in prostate cancer (Fixed Term)
Project supervisors: Dr Harveer Dev, Dr Simon Pacey (University Department of Oncology) and Dr Josep Forment (Oncology R&D, AstraZeneca)
Closing Date: 6 October 2023
Applications are invited for 4-year PhD studentship based in the Department of Oncology, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr Harveer Dev, Dr Simon Pacey (University Department of Oncology) and Dr Josep Forment (Oncology R&D, AstraZeneca) and will have the opportunity to work across the two sites. The project, entitled DNA damage and androgen pathway inhibition in prostate cancer will explore the interplay between these two pathways, placing you at the intersect of cutting edge biological, translational and clinical research.
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- Project Title: Investigate the mechanistic link between chronic kidney disease and cardiac dysfunction (Fixed Term)
Project Supervisors: Dr Xuan Li, Dr Kevin Woollard and Dr Weike Bao (AstraZeneca)
Closing Date: 1 October 2023
Applications are invited for 4-year PhD studentship based in the new Victor Phillip Dahdaleh Heart & Lung Research Institute (VPD-HLRI), University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr Xuan Li (UoC, https://www.xuanlab.org) and Dr Kevin Woollard & Dr Weike Bao (AstraZeneca) and will have opportunity to work across the two sites in several locations (Cambridge UK, Gaithersburg USA, Gothenburg Sweden). This project will use multidisciplinary approaches (biochemistry, cell biology, human induced pluripotent stem cell and etc.) to investigate the regulation of microtubule-dependent mechanisms in cardiorenal diseases.
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- Project Title: The role of macrophages in endometrial carcinoma
Project Supervisors: Dr. Naomi McGovern at the Department of Pathology, and Dr. Elina Timosenko and Dr. Tim Slidel at AstraZeneca
Closing Date: 6 October 2023
Applications are invited for 4-year PhD studentship based in the Department of Pathology, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr. Naomi McGovern at the Department of Pathology, and Dr. Elina Timosenko and Dr. Tim Slidel at AstraZeneca and will work across the two sites. The project, entitled "The role of macrophages in endometrial carcinoma" is in the fields of immunology, oncology and bioinformatics that have generated much excitement in both academia and industry.
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- Project Title: Expanding the toolbox of molecular degraders through systematic degron discover
Project Supervisors: Dr Richard Timms (University of Cambridge) and Dr Sergio Martínez Cuesta (Astrazeneca)
Closing Date: 9 October 2023
Applications are invited for a fully funded, four-year PhD studentship based at the Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID) and the new AstraZeneca Discovery Centre on the Cambridge Biomedical Campus. This is a collaborative project between the laboratories of Dr Richard Timms (University of Cambridge) and Dr Sergio Martínez Cuesta (AZ), and the student will have the opportunity to work across both sites.Towards the goal of enhancing the rational design of novel PROTACs, this project will combine cutting-edge wet-lab and dry-lab techniques to explore the fundamental mechanisms through which E3 ubiquitin ligases target their substrates.
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- Project Title: Mining the microbiome: how do gut microbes modulate visceral pain?
Project Supervisors: Prof. Ewan St. John Smith (Pharmacology) and Dr John Linley at AstraZeneca
Closing Date: 31 October 2023
Applications are invited for 4-year PhD studentship based in the Department of Pharmacology, University of Cambridge and the new AstraZeneca Discovery Centre in Cambridge. The student will be working on a collaborative project jointly supervised by Prof. Ewan St. John Smith (Pharmacology) and Dr John Linley at AstraZeneca and will have opportunity to work across the two sites. The aim of this project will be to investigate the cellular mechanisms by which human gut microbes modulate visceral pain using functional recordings from pain sensing neurons, nerves and in vivo behavioural experiments in models of visceral pain.
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- Project Title: Multimodal AI-guided tools for early prediction of disease progression in neurodegenerative disorders
Project Supervisors: Zoe Kourtzi (Psychology) and Keith Tan at AstraZeneca
Closing Date: 20 November 2023
Applications are invited for 4-year PhD studentship based in the Department of Psychology, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Professor Zoe Kourtzi at Department of Psychology Cambridge in collaboration with AstraZeneca's Neuroscience (Dr Keith Tan, Dr Andrew Lowe) and Data Science & AI (Dr Philip Teare, Dr Gayathri Mohankumar) teams and will have the opportunity to work across the two sites. The project focuses to develop an innovative data-driven approach that capitalises on state-of-the-art algorithms from artificial intelligence (foundational models) to mine multimodal data from polygenic risk scores, MRI scans, biomarkers and cognitive tasks for early prediction of disease progression.
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- Project Title: The Chemical Antibody (ChemiAb): Synthetic Organic Chemistry and Chemical Biology
Project Supervisors: David Spring (Chemistry) and Andrew Buchanan at AstraZeneca
Closing Date: 01 December 2023
Applications are invited for a 4-year PhD studentship based in the Department of Chemistry and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof David Spring (University of Cambridge) and Dr Andrew Buchanan (AstraZeneca), and will have the opportunity to work across the two sites.The aim of the project will be to develop a new class of therapeutic with the specificity and half-life of an antibody, but a relatively easy and low cost of manufacture to make them globally applicable to treat disease. The project will involve both organic synthesis and chemical biology skills.
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- Project Title: Identifying opportunities to overcome the immunosuppressive role of Cancer-Associated Fibroblasts
Project Supervisors: Kourosh Saeb-Parsy (Surgery) and Massimiliano Mellone at AstraZeneca
Closing Date: 19 November 2023
Applications are invited for the Astra Zeneca PhD studentship in Identifying opportunities to overcome the immunosuppressive role of Cancer-Associated Fibroblasts. The post is based primarily in the University of Cambridge Department of Surgery on the Cambridge Biomedical Campus, with some time based at Astra-Zeneca. The proposed start date is October 2024. The successful candidate will be expected to fully integrate into both Prof Saeb-Parsy and Dr Mellone's research groups in the University of Cambridge and AstraZeneca respectively. They will be trained in a wide range of laboratory techniques, including but not limited to 2D and 3D cell culture, flow cytometry, immunofluorescence, qPCR, DNA and RNA sequencing and animal (mouse) experimentation.
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- Project Title: Interactions of non-covalent biologics at the single-molecule level
Project Supervisors: Steven Lee (Chemistry) and Praveen Kallamvalli Illam Sankaran at AstraZeneca
Closing Date: 31 November 2023
Applications are invited for 4-year PhD studentship starting in October 2024 based in the Yusuf Hamied Department of Chemistry and the new AstraZeneca Discovery Centre on the Cambridge Biomedical Campus. The student will be working on a collaborative project jointly supervised by Prof Steven Lee (University of Cambridge) and Dr Praveen Sankaran (AstraZeneca) and will have opportunity to work across the two sites. The project is in the general field of single-molecule microscopic techniques and antibody biologics that has generated much excitement in both academia and industry. This project offers a unique opportunity to work at the interface of physical chemistry, protein chemistry and structural biology in both academic and industry settings, and by the end of the studentship you will have gained a broad range of key experimental, computational and transferable skills that will serve as a springboard for a successful research career.
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- Project Title: Unravelling and predicting toxicity of Antibody Drug Conjugates in the lung using genome-wide multi-omics and CRISPR-Cas9
Project Supervisors: Vito Mennella (MRC Toxicology) and Jennifer Tan at AstraZeneca
Applications are invited for 4-year PhD studentship based in the Department of Physiology, Development and Neuroscience and the MRC Toxicology unit in the School of Biological Sciences at U. of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr Mennella in in the MRC Toxicology Unit and Dr Emma Rawlins in Department of Physiology, Development and Neuroscience in the School of Biological Sciences at U. of Cambridge and Dr Jennifer Tan, Dr Benedicte Recolin, Dr Kelly Evans and Dr Catherine Betts at AstraZeneca and will have the opportunity to work across the two sites. The project, entitled "Unravelling and predicting toxicity of Antibody Drug Conjugates in the lung using genome-wide multi-omics and CRISPR-Cas9" aims at leveraging knowledge in airway biology and Omics technologies to understand why Antibody Drug Conjugates, a promising new drug modality with high efficacy against lethal cancers can cause adverse response limiting their use.
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- Project Title: Advancing Diffusion Models in Medical Imaging: Enhancing Denoising, Reconstruction, and Clinical Impact
Project Supervisors: Carola-Bibiane Schönlieb (Applied Maths and Theoretical Physics) and Richard Goodwin at AstraZeneca
Applications are invited for 4-year PhD studentship based in the Department of Applied Mathematics and Theoretical Physics (DAMTP), and in collaboration with AstraZeneca. The start date will be October 2024. The student will be working on a collaborative project jointly supervised by Prof. Carola-Bibiane Schönlieb (DAMTP), Dr Angelica Aviles-Rivero (DAMPT) and Dr Richard Goodwin (AstraZeneca). Diffusion models have proven to be powerful tools for data modelling and analysis. They offer a versatile framework for capturing complex patterns and dynamics in various domains. In this funded PhD opportunity, we aim to push the boundaries of diffusion models by combining theoretical aspects with practical challenges, with a specific emphasis on continuous-time stochastic processes.
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